Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan maleimide Product Name DOTA-NHS Synonyms CAS
Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan maleimide Product Name DOTA-NHS Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is
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