Azide-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8) carboxylic ester It binds to the VHL

It binds to the VHL E3 ligase with an IC50 of 0

NC1CCN(CC1)C1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC): 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Additionally

1038/s41557-019-0371-1

99 SMILES Cl

Azide-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8) carboxylic ester It binds to the VHLSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Azide Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase