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The pre-BBA amount is the product of the hospital's reasonable costs for covered outpatient department services occurring in the current year and the base payment-to-cost ratio (PCR) for the hospital defined in section 1833(t)(7)(F)(ii) of the Act

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Based on these observations it was concluded that folding of permuted dihydrofolate reductase variants was terminated at the stage of the molten globule formation, whereas their interaction with ligands promoted structural adjustments and formation of active protein molecules, indicating ligand-induced transition from the molten globule to the native state (Uversky et al., 1996)