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Nat Rev Neurosci 15(1):4353 Yamada ES, Respondek G, Mssner S, De Andrade A, Hllerhage M, Depienne C et al (2014) Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice

Its also crucial to follow the manufacturers recommendations on the product label while ashwagandha is generally considered safe, excessive intake may cause side effects such as vomiting or diarrhea

Neuroinflammation can directly or indirectly exacerbate oxidative stress in the brain, predisposing neurons to damage and death [3]

But if taken without consulting a doctor, it may lead to disorders in the thyroid gland and hormones, as well as lead to kidney failure or an allergic reaction

Tkel, R., Aydin, K., Ertekin, E., zyildirim, S