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Table 1, although first-generation antifibrotic drugs, such as pirfenidone and nintedanibapproved over a decade agohave demonstrated efficacy in slowing IPF progression and improving survival rates in clinical trials, their benefits are constrained by significant side effects (e.g., nausea, diarrhea, and photosensitivity) that compromise long-term tolerability (King et al., 2011

The sustained upregulation of these pathways contributed to the development of several diseases [6, 7]

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Echocardiographic analysis revealed no significant change in the basic cardiac function of the overexpression group

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