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Unlike other treatments, enclomiphene has a unique dual effect: it boosts testosterone while lowering the IGF-1 hormone and the human growth hormone (HGH), the latter of which is important for various bodily functions

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Due to General Data Protection Regulation, patients who were still alive had to provide approval for the retrieval of long-term data and were contacted by either mail, or telephone, and by means of an information letter and study questionnaire

Among the 25% of GBMs exhibiting ser/gly pathway hyperactivation, ~13% of cases harbor genetic amplifications and mutations in PSPH, underscoring the significance of PSPH and de novo ser/gly synthesis pathway in the pathogenesis of GBM [21]