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Engstrom, E., Niklasson, A., Wikland, K

Intrinsic physiochemical distinctions in the tumor microenvironment Tumor microenvironment offers diverse characteristics, including but not limited to (i) tumor acidity (pH 6.57.2)

The generated ROS can trigger the Mitogen-activated protein kinase signaling route (MAPK), thereby activating p38 MAPK, ERK, and JNK, leading to glomerulosclerosis, renal interstitial fibrosis, damage caused by oxidative stress, pancreatic -cell apoptosis, inflammatory responses, and increased collagen synthesis in cells

This suppression decreased mitochondrial GSH and increased ROS production

2022 Jan 7;12(1):135