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Figure 5 Recently, we demonstrated an abundance of Fe(II) in the lumina of renal proximal tubules after Fe-NTA injection (Mukaide et al., 2014) with a novel fluorescent probe (RhoNox-1) specific for catalytic ferrous iron (Hirayama et al., c-Met (receptor for hepatocyte growth factor) and deletion of Cdkn2a/2b ( p16 Ink4a / p15 Ink4b tumor suppressor genes) are most common (Tanaka et al., 1999