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This patients severe obesity, hyperphagia, and metabolic syndrome led to suspicion and confirmation of a genetic cause

mROS, mitochondrial ROS

However, lipid peroxidation can damage DNA, protein, lipids and eventually lead to cell death

Many dietary supplements also claim to aid weight loss, but their efficacy and safety are often questionable

Liu and associates (256) analyzed sodium iodate (SI)-induced AMD cellular models and discovered that SI, while not influencing GPX4 activity, could deplete intracellular GSH, liberate Fe 2+ from liposomes, increase intracellular ROS production, and increase lipid aggregation, consequently precipitating ferroptosis in ARPE-19 cells