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Regular B12 injections are the only treatments that seem to work, as excess amounts of Vitamin B12 are not stored in the body but rather excreted (it is a water soluble vitamin)

Hydroxyl free radicals produced by cisplatin are involved in the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and the regulation of TNF- synthesis, ultimately inducing the activation of NF-B

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Problems with intrinsic factor binding to ileal receptors in the diseased tissue leads to B12 deficiency