MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 3-benzodiazole Synonyms CAS Number n/a

3-benzodiazole Synonyms CAS Number n/a Related CAS Molecular Formula C8H7BrN2 Molecular Weight 214

57 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCCN=[N]#N)=[N+](C)C)=C1

Methylcyclopropene-CA CAS Number Related CAS Molecular Formula C16H28ClNO4 Molecular Weight 333

and a brief treatment with 100 mM MESNA results in a near-complete loss of fluorescence

S)-AHPC-CO-PEG3-C2-azide Synonyms CAS Number n/a Related CAS Molecular Formula C31H45N7O7S Molecular Weight 659

MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 3-benzodiazole Synonyms CAS Number n/aSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,