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Ong KL, Stafford LK, McLaughlin SA, Boyko EJ, Vollset SE, Smith AE, Dalton BE, Duprey J, Cruz JA, Hagins H, et al

MPP + treatment significantly reduces TIGAR expression in HT22 cells, downregulates NADPH, GPX4, and GSH levels, upregulates GSSG levels and the GSSG/GSH ratio, decreases adenosine triphosphate (ATP) production, and promotes neuronal ferroptosis, iron-dependent lipid peroxidation, and mitochondrial dysfunction, thereby exacerbating neuronal cytotoxicity

The results showed that dupilumab therapy, as compared with placebo, was associated with fewer asthma exacerbations when LABAs and ICSs were withdrawn accompanied by improved lung function and reduced levels of TH2-associated inflammatory markers

These concentrations have also been used by others 14,34,35 , including ourselves 42 allowing us to compare our results with published studies

If we do, we need a -25 modifier on the E&M