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Advanced in situ imaging and sampling techniques, combined with longitudinal multi-omics studies in well-characterized patient cohorts, are essential to capture this dynamic interplay and to identify personalized modulators of this axis

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Raised ROS level is a critical contributor to the initiation and development of vitiligo pathophysiological processes (Bergqvist and Ezzedine, 2021)

However, no genes encoding proteins associated with glutathione metabolism could be identified to be differentially regulated, though, on the metabolome level, metabolites belonging to the glutathione metabolism were detected in the co-culture cells (Fig