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In line with these findings, several preclinical and clinical studies have shown that multiple anticancer drugs (e.g., umbralisib and CX-4945) targeting the CK1 or CK2 family exhibit unique immunomodulatory effects in the treatment of hematological cancers, such as chronic lymphocytic leukemia, other non-Hodgkin lymphomas, myelodysplastic syndrome, AML and multiple myeloma (MM) 81,82

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