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When a standardized and highly controlled process of differentiation is applied in vitro , the resulting difference of iPSC-derived neurons from healthy donors should mainly depend on the original genetic makeup related to the disorders, allowing the assessment of the modulatory effects of genetic mutations on cellular functions (Penney et al., 2019)

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Vitamin D deficiency induces the excitation/inhibition brain imbalance and the proinflammatory shift

However, no difference was observed in efficacy between ketamine and placebo