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Meanwhile, human clinical data are generally characterized by small sample sizes and short follow-up periods, with inadequate adjustment for confounding factors such as diet and concurrent medications, making it difficult to confirm the long-term efficacy and safety of Clostridium interventions

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In terms of future research directions, large-scale, randomized, placebo-controlled clinical trials must be conducted that fully consider the effects of potential confounding factors to clarify the long-term effects of SSRIs on male and female fertility, to assess the recovery of reproductive function after drug discontinuation, and to clarify their reversibility

It also costs roughly 20 to 30 percent more than injection