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Secondary outcomes included biochemical redox markers such as blood GSH, cerebrospinal fluid (CSF) GSH, GSSG, and GSH/GSSG ratio and imaging-based functional outcomes, particularly DAT binding assessed by DaTscan SPECT

Factors such as heterogeneous clinical manifestations, geographic dispersion, limited patient numbers and high disability rates exacerbate these challenges

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Methane-dominant SIBO (now often referred to as IMO - intestinal methanogen overgrowth) is more often associated with constipation