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The high cost of fully individualized organoid-chip testing represents a major barrier to its use as a universal screening strategy because the Gut-on-a-Chip model requires patient-specific organoid generation, chip culture, and functional validation

This synergistic strategy generates a more profound and durable antitumor immune response, establishes potent memory T-cell populations, and significantly increases the likelihood of effective tumor eradication and long-term protection

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