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Kohno K, Koya-Miyata S, Harashima A, Tsukuda T, Katakami M, Ariyasu T, et al

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Women who were pregnant, lactating, or had not adhered to adequate contraception from at least 30 days prior to the study entry and did not plan to for 1 month after the final supplementation were also excluded

Small, 1.5-cm plastic cylinders, 1-cm diameter, were fashioned and placed on the base of their tails in order to prevent the mice from successfully climb their tails, as the C57BL/6 mice are notorious for climbing during the test [62]