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therefore, we speculate that, their alterations within the NAc, which is a critical brain circuit for addictive processes, may enhance the development of aberrant synaptic connections and plasticity underlying nicotine dependency ( Role of Microglia in Nicotine-Induced Inflammation Activated microglia produce and release a variety of pro-inflammatory cytokines and augmenting the production of free radicals ( Variable Effects of Nicotine on Adult and Adolescent Microglia Morphological Differences Significant morphological differences exist between adult microglia and adolescent microglia, adult microglia were larger and have more complex morphology than adolescent microglia

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