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The published research literature describes GHK-Cu as exerting effects through multiple coordinated mechanisms: stimulation of fibroblast proliferation and migration

J Pharmacol Exp Ther 2010

2 Methodology A comprehensive literature search was conducted in scientific databases including PubMed, Web of Science, ScienceDirect, Google Scholar, WanfangData, Chinese Pharmacopoeia, and China National Knowledge Infrastructure (CNKI) using keywords such as Astragalus , Astragalus L., Astragalus spp., Astragalus , Astragali radix , and Astragali complanati semend

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Diabetic wounds exhibit decreased Ym1 and Arginase expression with increased expression of IL-17 and IL-20