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Second, if the structure was present in PubChem or CAS SciFinder, we manually reviewed all of the associated literature references to establish whether any of these reported its detection in mammals

The most dominant DNA lesion formed by ROS is 7,8-dihydro-8-oxo-deoxyguanosine (8-oxo-dG) which causes G:C to T:A transversions (Grollman and Moriya, 1993

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