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The results are striking: across benchmarks involving unseen cell types, unseen drugs, and even different experimental platforms, CRISP outperforms existing methods (e.g., +24.5% correlation gain on held-out cell types)

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Existing blood biomarkers such as glycated hemoglobin are effective in predicting diabetic complications, e.g., microangiopathy and retinopathy 41,42

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In the yeast and mammalian cytosol, the thioredoxin pathway was considered to be the major reductive pathway with the glutaredoxin/glutathione system having only a back-up or auxiliary role [38, 40]