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Transcriptionally, V-organoids shared a common profile with crypt-derived collagen organoids during the primary phase, while their profile was in marked contrast to that of Matrigel organoids in bulk RNA sequencing analyses (Fig

Hum Mutat 25:1821 Schaub A, Futterer A, Pfeffer K (2001) PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily

Peptides, made from short chains of amino acids are the unsung heroes of the biological world, playing a huge role in many physiological processes

All of the above factors that induce CD8 + T-cell exclusion contribute to an immunosuppressive TME, which represents a fundamental mechanism underlying most immunological cold tumors that are unresponsive to anti-PD treatment and other forms of immunotherapy [187]