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Furthermore, acidosis failed to induce GLS2 and G6PD in several breast cancer cell lines with mutated p53 (T47D and MDA-MD-231) (Figure 6A,B, Additional file7: Figure S6D)

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In a further minor reaction, fatty acids can undergo -oxidation with the eventual production of dicarboxylic acids, and carnitine esters of these can be present in the plasma of patients with peroxisome biogenesis disorders

In neurons, pioglitazone exhibits anti-ferroptosis activity in neurons by increasing the expression of PPAR-, downregulating cyclooxygenase-2 (COX2) expression (Liang et al., 2022), and cooperating with Nrf2(74)

B12 deficiency also disrupts homocysteine metabolism