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Additionally, it is unexplored whether the intestinal virome modulates autophagy via NOD2

In melanoma, ROS is also capable of ectopic peroxisome proliferator activated receptor- from the nucleus into the cytoplasm via mitogen-activated protein kinase kinase 1, thereby inducing an increase in TNF-, which not only plays an antitumor role, but also converts TAMs into a phenotype that promotes tumor invasion (112)