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Consistent with the idea that this axis is required for resistance to DNA-damaging agents, knockdown of either CrAT or CrOT, which decreased histone acetylation (Extended Data Fig

Another study suggests that PCa cells resistant to Gln inhibition may also resist radiation-induced damage by activating the ATG-mediated autophagy pathway ( Figure 3 4.3.2 Targeted Gln combined immunotherapy In the tumor microenvironment, competition for Gln between tumor cells and immune cells significantly impacts anti-tumor immunity

doi: 10.3389/fgene.2022.795820 165 NakanoYNaoeTKiyoiHKunishimaSMinamiSMiyawakiSet al

Genetic mutations, such as in the FMR1 gene (fragile X messenger ribonucleoprotein 1), have been linked to genetically induced POF (Ojavee et al., 2023)

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