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Principal Investigator on A Randomized, Double-blind, Multicentre, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants with Major Depressive Disorder (MDD) with Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy. Principal Investigator on A Study of Disease Characteristics and Real-life Standard of Care Effectiveness in Patients with Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including an SSRI or SNR. (Janssen)

These familial forms are linked to mutations in over 20 genes, most notably C9ORF72, Cu/Zn superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and fused in sarcoma, many of which converge on pathways critical for RNA metabolism and protein homeostasis [310,313]

345 Moreover, periodontitis has been reported to be closely associated with IBD

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doi: 10.1016/j.abb.2019.07.024 52 PoloczanskaE