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A Cochrane review supports the use of high-dose vitamin B 12 (1 mg and 2 mg daily) in elevating serum vitamin B 12 level and achieving haematological and neurological responses, even in patients with PA or with ileal resection.58 The recommendation for oral replacement is 1 mg daily for a month, and then 125 to 250 g daily as maintenance dose for patients with dietary insufficiency and food-cobalamin malabsorption, while for PA the maintenance dose is 1 mg daily.29 Vitamin B 12 does not have side-effects even when prescribed in large doses.59 However, hypokalaemia, resulting from uptake of circulating potassium by newly growing and dividing haematopoietic cells, can be severe or sometimes life-threatening

Because it chemically disables the NNMT enzyme, it effectively removes the biological "brakes" on fat burning

Researchers drawing direct efficacy conclusions between these two compounds from the existing literature are working from an inference, not from controlled comparative data

By using 5-Amino-1MQ to inhibit this enzyme, scientists were able to rejuvenate these cells in elderly mice

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