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2009), while other AAV serotypes have been used for targeting other cell populations in the CNS, such as astrocytes (Hanlon et al

Ebell MH, Siwek J, Weiss BD, Woolf SH, Susman J, Ewigman B, Bowman M

Springer , Newyork

While enzymes such as glutathione peroxidase 4 (GPx4) typically utilize cellular glutathione (GSH) stores to scavenge lipid hydroperoxides and prevent LPO-induced damage, erastin-mediated inhibition of cysteine uptake through the Xc- transporter compromises this defense strategy, leading to cell death