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Researchers have also observed that glutathione regulates protein function through reversible S-glutathionylation of cysteine residues, modulating the activity of signaling proteins, transcription factors, and metabolic enzymes in response to oxidative conditions

In addition, chronic hyperglycemia enhances mTOR and inhibits AMPK which is associated with decreased PDH activity and may underlie reduced oxidative metabolism during T2D-related diabetogenic metabolic stress (Haythorne et al., 2022)