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In contrast, both Mock and MST6-I cells treated with secretomes from white or beige-like adipocytes showed increased expression of genes associated with lipid remodeling ( AIG1, PLA2G1, and PLA2G4F) and polyunsaturated fatty acids metabolism ( MFSD2A , ACOX2, and CYP2C19 )

HDAC6 WB is shown as a loading control

13.5 Balancing safety with clinical benefit Among the primary safety concerns associated with probiotic administration are opportunistic infections, as immunocompromised individuals face a significantly increased risk of systemic infections originating from probiotic strains