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Neuropathy scores improved in seven patients, mostly in patients with immune-mediated neuropathy, but remained unchanged or worsened in the remaining five patients (two patients dropped out due to adverse events that were considered unrelated to B12)

119 In addition, other signalling pathways, such as the noncanonical Wnt, JAK/STAT, and Hedgehog (Hh) pathways, exhibit signalling crosstalk with the Wnt/-catenin signalling pathway, jointly achieving the regulation of bone homeostasis