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159 Mechanistically, ZIP7 overexpression induces zinc mobilization from the ER and Golgi, 341 triggering tyrosine kinase signaling as well as enhancing the aggressiveness of MCF7 cells 148,339 (Fig

109 : 11251131 Cai Y, Zhang C, Nawa T, Aso T, Tanaka M, Oshiro S, Ichijo H and Kitajima S (2000) Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element

All these mechanisms cooperate to provide a sensory readout from more than one subcellular compartment with varying sensitivity to amino acids, thus leading to the tight control of the metabolic state

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