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This discrepancy between mechanistic rationale and clinical outcomes represents a critical challenge in rheumatology, forcing a re-evaluation of how well our preclinical models truly capture the drivers of established axial disease

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"American College of Medical Genetics statement on folic acid: fortification and supplementation"

38 Mitochondrial disorders such as Leigh syndrome involve impaired energy production due to dysfunctional mitochondria, which disrupts the energy supply needed by neurons and results in neurodegeneration

W., Wu, J., Zhang, Y., Yan, F