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Cell-nonautonomous function of ceramidase in photoreceptor homeostasis

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Its main mechanism of action would be its ability to bind to serum calcium, preventing activation of the coagulation cascade and prolonging the time till blood clot formation

On the basis of data on irritancy in humans, a tolerable concentration can be derived as follows: 45 mg/m 3 Tolerable concentration = = 2 mg/m 3 (2000 g/m 3 ) 20 where: no effects were observed in a limited study on human volunteers at 45 mg/m 3 (Silverman et al., 1946) and 20 is the uncertainty factor (10 for intraspecies variation and 2 for the poor quality of the data)

Retrieved June 5, 2012