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Multiple cellular problems attributed to dysregulation of GSH and GSH-dependent enzymes contributes to impairment in the function of mitochondria, elevation in oxidative damage, disruption of intracellular signal transduction pathways, protein aggregation, and eventually cell death

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In synthesizing the data, we organized the findings according to the major classes of functional food compounds, highlighting their mechanistic diversity, therapeutic promise, and key challenges in clinical application

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