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Friedman M, Levin CE (2012) Nutritional and medicinal aspects of D-amino acids

Generally, the described amino acids are safe: however, high-dose protein or certain amino acids can cause digestive upset (e.g., L-arginine might cause mild diarrhea at 9 g for some [167], and NAC can cause nausea for a minority [168])

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The alteration in monoterpene and phenylpropanoid pathways indicates that selenium and iodine profoundly influence secondary metabolism