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Pemetrexed can cause bone marrow function to decrease, which may lead to a reduction in blood cells

At the same time, hypoglycemia upregulates B56, the PP2A regulatory subunit, resulting in the formation of a PP2A-B56 active complex with a high affinity toward GSK3 to specifically activate the PP2A-GSK3 axis, leading to a decline in the pro-survival protein MCL-1, thereby interfering with glycolysis in hepatocellular carcinoma cells (81)

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As is known, vascular endothelial levels are closely correlated with the concept of angiogenesis (Callahan et al