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Phase One: Transformation In the first phase, the liver uses enzymes to take a toxin and turn it into a more reactive form

Furthermore, short-chain fatty acids such as butyrate produced by periodontopathic bacterial metabolism may participate in upregulating ACSL4 expression through epigenetic regulation, although the underlying mechanisms remain to be further elucidated (27)

Furthermore, genetic polymorphism in GSTs is pressumed to influence metabolism and disposition of various anticancerogenic drugs (Crettol et al., 2010)