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Demyelination and autoimmune models Experimental autoimmune encephalomyelitis (a multiple-sclerosis analog) and toxin-induced demyelination let investigators watch oligodendrocyte progenitor cells proliferate and mature using BrdU labeling and myelin markers such as myelin basic protein

Interestingly, we also show that kynurenine, a metabolite derived from tryptophan following inflammatory activation of IDO1 [46,47,48], is elevated in TTR-V30M patients but not in age-matched healthy controls

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Table 1 Primer sequences for the genes observed in qRT-PCR