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the study excluded individuals with comorbid neurological, metabolic, genetic or psychiatric conditions, including epilepsy, fragile X syndrome, tuberous sclerosis, PKU, fetal alcohol syndrome and any acute or chronic medical illness

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Considering the newly identified role of amino acid metabolism in macrophage polarization, we are optimistic that exploiting NMs to regulate amino acid metabolism within macrophages to emerge the desired phenotype will be a new research direction, although the blueprint is premature

You et al., 2009)