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Tirzepatide is a first-in-class dual incretin receptor agonist a single molecule that activates both the GIP (glucose-dependent insulinotropic polypeptide) and the GLP-1 (glucagon-like peptide-1) receptors, which is why it is often nicknamed a twincretin. [7] By engaging two incretin pathways it enhances glucose-dependent insulin secretion, promotes satiety, and delays gastric emptying, producing large effects on both glycemic control and bodyweight

An intravaginal live Candida challenge in humans leads to new hypotheses for the immunopathogenesis of vulvovaginal candidiasis

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Cell culture and regents The Jurkat human T cells were obtained from the American Type Culture Collection (Manassas, VA, USA)

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