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4.2 Reduction of oxidative stress Active metabolites from TCM show significant potential in regulating the level of oxidative stress in UC, mainly through their interaction with the PI3K/Akt signaling pathway

TYAS, University of Melbourne, Melbourne VIC, Australia 10

Kaufmann, M., Lee, S

2024 Apr;131(7):1125-57

188 Under excessive ROS, p53 plays a crucial role in promoting ferroptosis by negatively regulating SLC7A11, leading to decreased GSH and increased sensitivity to ferroptosis by limiting the antioxidant capacity of cells