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Given that muscle contraction places an immense physiological load on bone, the strength of bone must be adapted to muscle strength ( igf-1 global knockouts, the osteopenic phenotype is accompanied by muscle hypoplasia attributed to reduced number of cells but not of cell size ( in vitro and in vivo ( Although a detailed characterization of muscle phenotypes has yet to be performed, osteoprogenitor igf-1r ( Osterix-Cre igf-1r ) and Cart igf-1r conditional knockouts, display proportionately smaller muscles concomitant with a shorter and smaller skeleton (unpublished qualitative observations)