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The mammalian target of rapamycin (mTOR), a key protein downstream of the phosphatidylinositol 3-kinase/protein kinase (PI3K/AKT) pathway, is closely associated with insulin metabolic dysfunction and exerts a substantial impact on the growth and proliferation of FGCs

In all assays the reactions were performed in 1 ml 0.1 M potassium phosphate (pH 7.4), 10 mM EDTA using 100 M NADPH and 20 nM TGR

This effect is achieved by promoting GDH1 expression through the downregulation of the epidermal growth factor receptor (EGFR)/MEK/ERK signaling pathway [56]

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