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[42] [43] Clinical responses to JAK inhibitors, [44] [45] [46] [47] [48] anti-IFN therapy, [49] and agents targeting the interferon receptor support the importance of this pathway in disease activity

To challenge the hypothesis that multiple tRF-derived sequences could yield informative PD biomarkers, we searched for tRF families that share common sequence motifs whose levels are changed in the brain, blood and/or CSF of patients with PDall biofluids known to reflect cerebral pathologies, including PD 22,37