Thus, the dynamic interaction between microglia and astrocytes, mediated by specific cytokine and chemokine signaling pathways, critically determines neuroinflammatory trajectories and influences both degenerative and regenerative processes in CNS disorders (Jha et al., 2019
At the cellular level, CKD is remarkable by oxidative stress, abnormal autophagy, and mitochondrial dysfunction accompanied by significant alterations in cell signaling pathways such as HIF, TGF-, and p53 activation [21]
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Analysis in larger and more racially and ethnically diverse population will be needed to confirm and understand the generalizability of these findings Disclosures: Cristian Sanchez Torres: Nothing to Disclose, Ana Ramirez: Nothing to Disclose, Scott Gillespie: Nothing to Disclose, Helaina Huneault: Nothing to Disclose, Jack Knight-Scott: Nothing to Disclose, Adina Alazraki: Nothing to Disclose, Geetika Khanna: Nothing to Disclose, Claudia Yaranga: Nothing to Disclose, Nicola Santoro: Nothing to Disclose, Liliana Aguayo: Nothing to Disclose, Shasha Bai: Nothing to Disclose, Jean Welsh: Nothing to Disclose, Miriam Vos: Nothing to Disclose 865 EFFICACY OF NON INVASIVE TESTS (NITS) IN DIFFERENTIATING METABOLIC DYSFUNCTION-ASSOCIATED FATTY LIVER DISEASE (MAFLD) AND METABOLIC-ALCOHOL ASSOCIATED LIVER DISEASE (METALD)-META-ALD STUDY Harsh Tevethia 1 Guresh Kumar 2 Shiv Kumar Sarin 2 , 1 Institute of liver and biliary sciences,New Delhi India, 2 ILBS Background: MAFLD represents a global pandemic for liver diseases with a prevalence of 22% to 51% worldwide
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