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These findings support combined strategies that integrate standard therapies with drugs targeting mechanisms associated with DTP cells, as summarized in Table 4 , and underscore the importance of early intervention approaches to reduce the reservoir of cells capable of triggering a relapse

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The peak observed at around 1313 cm 1 corresponds to the stretching vibration of the C-N bond, while the peak at 2911 cm 1 is assigned to the C-H band [24]

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Consequently, the traditional perception of lactate as a mere metabolic waste product has shifted to a multifunctional signaling molecule and energy carrier, playing complex regulatory roles within the TME