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The cardiac fibroblasts are the main cell type in the heart wall that produces collagen, which is stimulated by hyperglycaemia, lipotoxicity and the release of pro-inflammatory cytokines

These results indicated that co-transfection of c-Jun with the DDD-Ube2e2-COP1 complex in cells leads to the formation of dimeric assembly, as shown by negative-stain EM and gel filtration analyses

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Jalpa Doshi reported receiving grants from Janssen Scientific Affairs, LLC during the conduct of the study